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Nearly two-thirds of formal sector workers in Mozambique belong to a labor union. Despite this, while considerable attention has been paid to encouraging private employers in Mozambique to adopt and implement HIV workplace policies and programs, until recently, organized labor had not been involved in efforts to support HIV interventions in the workplace. Collaborating with labor unions complements working with employers to facilitate the private sector response to HIV. This story describes how the Health Policy Initiative partnered with the National Confederation of Free and Independent Labor Unions of Mozambique (CONSILMO), which represents 106,000 members in four affiliated labor unions across Mozambique, to incorporate HIV workplace policies and programs as a standard demand in their collective bargaining efforts.